New Apple Ingredient Discovery Keeps Muscles Strong!

  by: Michael Clonts

Natural Component of Apple Peels Found To Help Prevent Muscle Weakening

In search of an effective method to prevent muscle wasting that comes with illness and aging, researchers have located a natural compound that is very promising.

The findings reported in the June issue of Cell Metabolism (a Cell Press publication), identify a natural component of apple peels known as Ursolic Acid as a promising newnutritional therapy for the widespread and debilitating condition that affects nearly everyone at one time or another.

"Muscle wasting is a frequent companion of illness and aging," explained researchers from The University of Iowa, Iowa City. "It prolongs hospitalization, delays recoveries and in some cases prevents people going back home. It isn't well understood and there is no medicine for it."

The research team first looked at what happens to gene activity in muscles under conditions that promote weakening. Those studies turned up 63 genes that change in response to fasting in both people and mice and another 29 that shift their expression in the muscles of both people who are fasting and those with spinal cord injury. Comparison of those gene expression signatures to the signatures of cells treated with more than 1300 bio-active small molecules led them to ursolic acid as a compound with effects that might counteract those of atrophy.

"Ursolic Acid is an interesting natural compound," they said. "It's part of a normal diet as a component of apple peels. They always say that an apple a day keeps the doctor away..."

The researchers next gave Ursolic Acid to fasted laboratory subjects. Those experiments showed that ursolic acid could protect against muscle weakening as predicted. When ursolic acid was added to the food of normal subjects for a period of weeks, their muscles grew. Those effects were traced back to enhanced insulin signaling in muscle and to corrections in the gene signatures linked to atrophy.

The subjects given ursolic acid also became leaner and had lower blood levels of glucose, cholesterol and triglycerides. The findings therefore suggest that ursolic acid may be responsible for some of the overall benefits of healthy eating.

"We know if you eat a balanced diet like mom told us to eat you get this material," the researchers explained "People who eat junk food don't get this."

It is not yet clear whether the findings will translate to human patients, but the goal now is to "figure out if this can help people." If so, they don't yet know whether Ursolic Acid at levels that might be consumed as part of a normal diet might or might not be enough.

Journal Reference:

mRNA Expression Signatures of Human Skeletal Muscle Atrophy Identify a Natural Compound that Increases Muscle Mass. Cell Metabolism

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Is it time to step up to a full service VPS hosting option?

by: MKenneth Feick

For anybody who is fed up with the inadequate overall performance of their shared web server but not yet in a position to step up to a costly dedicated server than the most suitable option available for you would be a Virtual Private Server (VPS).

The two main forms of VPS solutions are managed and unmanaged VPS services. Managed VPS hosting services are similar in a lot of ways to hosting that is shared. You'll receive skilled pros who will take care of any issues with your hosting server which could develop.

Managed VPS hosting servers are the most useful way to go if you're not very tech savvy or do not have the employees available to take care of any technical concerns that will arise with the hosting. You may also decide on Managed hosting if you're a business owner who just desires to focus on operating their business rather than concern yourself with if your server is functioning so that your clients can reach and use it. You can sleep well at night knowing your website is in safe hands.

Most good Managed VPS hosting providers will ensure you get 24/7 support that should quickly try to deal with any complications with your hosting server or if you would like to add new email accounts or domains to the server. It is possible to usually put in a simple request and this will be taken good care of.

A great company is Tecsys who make available both virtual offices in India among their services.

Unmanaged VPS hosting services will mean that you happen to be accountable for caring for your Windows or Linux server. Unmanaged servers tend to be made use of by businesses that either have proprietors that are technically very knowledge and can fix any problems that may crop up or they hire staff who are able to handle the problems on behalf of the company.

Although unmanaged VPS hosting is frequently less than managed hosting simply because you are not paying for the technical support nevertheless, you have to make sure you'll be able to take care of any technical issues that happen or you might find yourself with no functioning internet site for hours on end or even days which ultimately means that you end up paying much more in lost business than it would should you have had used a managed VPS hosting account.

If you're willing to take your online business to a higher level then you certainly should consider upgrading from a shared server to a VPS hosting account that you either are comfortable taking care of yourself or opt to have a great hosting company manage it for you.

TLC DIET

Diet TLC (Therapeutic Lifestyle Changes) is usually done to help lower bad cholesterol and reduce the risk of cardiovascular disease. The key to this type of diet is to reduce the intake of fat, particularly saturated fat, and get more fiber.

Clearly TLC diet is designed to raise levels of good cholesterol and not lose weight. But there are also studies that show generally low-fat diet can help you lose weight.

The experts reveal the diet is good for making a healthy heart. This is due to a diet that emphasizes fruits, vegetables and whole grains, but tend to be slightly saturated fat and salt. This method is good for maintaining normal cholesterol and blood pressure, so the risk of heart problems decreased.

To date there is no indication of the risk of serious side effects that may arise, and diet of the TLC diet is safe to do for children and adolescents.

Steps taken to implement the TLC diet

Start by selecting a target calories, then cut the saturated fat intake to less than 7 percent per day, which means reducing the high fat milk, butter and fatty meats.

In this diet a person is also asked to consume a lot of fruits, vegetables, whole grains, low fat dairy products or lean fish and poultry such as chicken without the skin.

Each day be eating meat no more than 5 ounces, including skinless chicken or fish, drink 2-3 servings of low or non-fat milk, eating 4 servings of fruit, 3-5 servings of vegetables, and whole grains, pasta, cereals or rice.

Fiber intake is mainly found in vegetables, fruits, nuts and seeds are the primary source that should be pushed on the TLC diet, most of the menu there is 40-50 grams of fiber daily.

In the TLC diet protein consumed 15 percent of the daily calories of protein (10-35 percent is usually recommended). Salt intake is restricted so as not to over-share, watch your intake of potassium and calcium in the blood vessels so that the muscles can work well.

THIS HOW TO NO EXCESSIVE SNACKING

Control hunger and prevent overeating can be overcome by taking a few snacks in between meals. But if you eat unhealthy snacks in excessive portions, it also can promote weight loss.

Overcome the desire is so great to eat snacks in order to successfully run a program of weight loss or maintain weight in order to stay slim. Here are 7 strategies to prevent excessive snacking:

1. Chewing gum

Most people spend time relaxing by watching TV, a movie or a ball game accompanied by a bag of popcorn or potato chips are salty and high in calories. This will certainly increase your weight slowly without you noticing.

Another alternative to accompany a relaxing time without the fear of weight gain, is by chewing a sugar-free gum.

2. Set the strategy on the go

People who are taking a long trip using a vehicle also can not be separated from cravings to get rid of boredom. To get around this, bring snacks in smaller portions and not the whole package.

Choose healthy snacks as well as choosing nuts, almonds, and fruit pieces and avoid salty or sweet snacks. Limit yourself to no snack snack in the way when you bring supplies have been exhausted.

3. Saving snacks into smaller containers

Purchase snacks are packed with small portions or if you want to save money by buying large packs, separated into containers smaller and store them in the pantry as supplies.

4. Readjust the position of food in the fridge or pantry

Put healthy food at the front of the fridge or cupboard foods and unhealthy snacks such as chips and so on in the back. So you will not be tempted to take a snack when opening the refrigerator.

5. Do not eat snacks at your desk

Avoid eating snacks at the office desk for office can associate with food. People who eat a snack at his desk, without conscious will continue to eat excessively in between jobs.

Conversely, if you eat a snack in the kitchen, cafeteria or in the office lounge, you will not eat excessively for fear of leaving a job for too long.

6. Eat only in the kitchen and dining room

Feeding activity should only be done in the kitchen or dining room in the house. Eating in front of the TV can make you overeat because of concentrating on what you see and not on what you eat.

7. Grab a snack at the right destination

Do not take snacks to accompany a reason to relax or relieve stress. Take snacks at certain hours in order to hold off hunger and prevent excessively large meals.

THINGS THAT THE RISK OF FERTILITY BOOST MEN

Infertility or fertility problems is not just a problem of women but also men. There are several factors that can cause fertility problems in men can cause infertility. What is it?

In the last 50 years, male fertility is expected to have declined by about 2 percent per year. Most fertility problems in men is caused by lifestyle choices are wrong.

Quote: Experts reveal that when a couple is infertile, then the third is caused by women, is caused by a third of men and a third can be caused by both.

Causes of infertility in men can be caused by genetics, but there are also related to lifestyle. Here is bebebrapa things that can increase the risk of men become infertile (infertile), namely:

1. Genetic Disorders

A genetic mutation can eliminate layers of carbohydrates around sperm thereby reducing mobility. If the two men inherited a genetic mutation from the mother and father, then this condition will make it difficult to impregnate a partner.

2. Obesity

Has any body obesity or being overweight makes the body unhealthy and thus affects the function of every cell in the body, including sperm.

3. Job

Some jobs can affect sperm count as painters, welders, builders, drivers and some office workers who sit too much because it makes the temperature increases in the scrotum.

4. Alcohol abuse

The man who became an alcoholic will have normal cells that are 30 percent less in the semen.

5. Sexual Problems

Some sexual disorders owned by men such as premature ejaculation or erectile dysfunction can make it difficult man to fertilize the female egg.

6. Smoke

One of the biggest negative impact that may be felt by men smokers were sperm motility.

7. Malnutrition

To have healthy sperm, then the required intake of nutrients such as vitamin C, zinc, vitamin E and beta carotene are sufficient.

8. Exposure to toxic substances

Frequent exposure to toxic substances such as those contained in pesticides or lead paint can damage sperm.

9. Use marijuana or other drugs

Men who use drugs such as marijuana or other can reduce the total number of sperm and semen volume than it has.

10. Often assuming the laptop

If you are using a laptop, you should put on the table or use the coating, since assuming the laptop can raise the temperature in the scrotum that affect the quality of sperm.

SOME CASES THAT HARM WHEN THE BODY TOO FAT

Obesity or overweight is very bad indeed even dangerous to health. Besides is not healthy, the body is too fat could actually harm in various ways.

Obesity is often the culprit of all the dangerous diseases such as heart disease, stroke, diabetes, cancer and others. Obesity can also make people less attractive and less confident.

Not only that, these people are too fat bodied may also experience adverse case,

1. Too fat to be a father

A father with a weight more than 163 pounds to lose custody of her two sons after a doctor told the court that he was too fat to be able to care for her children.

Male 38 years old from Ottawa, Canada, who was not named in court should strive to be able to maintain custody of her two sons aged 5 and 6 years old. He was also now have to undergo a weight loss program penurunkan if you want to get custody.

2. Too fat to fly

Kenlie Tiggeman is obese passengers who attracted media attention because in May, he claimed that the airline Southwest said he was too fat to fly. Now he was suing the airline.

3. Too fat to wear a wedding dress

Having set a date for the big day, Claire Donnelly was happy when choosing a wedding dress. Women 31 years was also ordered in a boutique Design in Gloucester. But his heart was broken when a boutique worker said he was too big to wear a wedding dress.

4. Too fat to be cremated

The bodies of obesity has led to a fire that nearly destroyed a crematorium in Austria. Investigators believe that the fire was enlarged due to burn fat from a woman's body has a weight of nearly 200 pounds, thus blocking the air filter which in turn causes the system to overheat filter.

Firefighters were able to control the fire, but the fire has caused considerable damage. Crematorium was closed for several days

5. Families who are too fat to work

4 people this weight when combined could reach 527 kg. Philip Chawner (53 years old) and his wife Audrey (57 years) both weigh 152 more. While her daughter Samantha (21 years) over 114 kg and the youngest Emma weighed 108 kg.

They have not worked for 11 years and claimed weight for hereditary conditions. In fact 'big family' is to spend time daily in front of the television.

LIVE LONG AND SLIM DIET

To achieve ideal weight, a lot of people who depend their life on a diet that manifold. But recently, a study from the United States have identified another potential of a special diet called the ketogenic diet as delay the aging process.

The team of researchers from the Gladstone Institute suggests that a diet that emphasizes low-calorie diet and carbohydrates that can trigger the production of a compound that plays an important role in delaying the aging process.

If the concentration is low, a compound called beta-hydroxybutyrate (beta-OHB) or 'ketone body' can help protect body cells from oxidative stress that contributes to the aging process.

Oxidative stress occurs when the body's cells use oxygen to produce energy but besides that this activity also resulted in the release of other toxic molecules known as free radicals.

The problem is when the age, the body's cells are no longer effective in clearing these molecules free radicals causing cell damage, oxidative stress and the effects of aging. But the researchers found that beta-OHB was really able to help delay the process.

"We found that beta-OHB, one of the body's main source of energy when exercising or fasting, can inhibit the formation of enzymes that promote the emergence of 'oxidative stress' and protects cells from aging," said researcher Eric Verdin zeenews quoted as saying on Monday ( 10.12.2012).

These findings obtained by the research team after passing a series of experiments involving a number of participants were asked to chronic calorie restriction diet. From there it was seen that calorie restriction triggers the production of beta-OHB that can inhibit the activity of a group of enzymes called histone deacetylase, or HDAC.

Investigate a calibaration, apparently normal existence HDAC this 'work' deadly pair of genes called Foxo3a and MT2. But with increased levels of beta-OHB, these compounds can inhibit HDAC doing it or in other words a pair of genes had finally become active. Whereas once activated, they can start an activity to help the body's cells against oxidative stress siege.

"This breakthrough also expand our understanding of the mechanisms behind long known HDAC involvement in aging and neurological diseases such as Alzheimer's, Parkinson's, autism and traumatic brain injury disease that has had few treatment alternatives," said another researcher, Katerina Akassoglou.